• Vosevi

    Drug: Vosevi (voh-SEV-ee)

    Summary

     

    Vosevi is a combination of three drugs—sofosbuvir (polymerase inhibitor), velpatasvir (NS5A inhibitor), and voxilaprevir (protease inhibitor) combined into one pill taken, once-a-day for 12 weeks.  It is approved by the Food and Drug Administration (FDA) to treat adults with chronic hepatitis C with and without compensated cirrhosis.  Vosevi is manufactured by Gilead Sciences Inc.

    It is approved to treat patients with the following characteristics:

    • HCV genotype(s) 1, 2, 3, 4, 5 or 6 who have been previously treated with a HCV therapy containing an NS5A inhibitor,
    • HCV genotype(s) 1a, or 3 infection and have been treated with an HCV therapy containing sofosbuvir without an NS5A inhibitor
      • Additional benefit of treatment with Vosevi over sofosbuvir/velpatasvir was not shown in adults with genotype 1b, 2, 4, 5 or 6 infection previously treated with sofosbuvir without a NS5A inhibitor.

     

    The overall cure rates of Vosevi are 91% to 100% in patients who had ...

  • Harvoni

    Drug: Harvoni (har-VOE-nee)

    Summary

    harvoni image

    Harvoni is a combination of two drugs – ledipasvir (NS5A inhibitor) and sofosbuvir (polymerase inhibitor) combined into one pill, taken once-a-day. Harvoni is taken with or without food. Harvoni is approved by the Food and Drug Administration to treat adults infected with hepatitis C (HCV) genotype 1, 4, 5 and 6. It can be taken with and without ribavirin. Harvoni is manufactured by Gilead Sciences Inc.

    The overall cure rates of Harvoni are up to and over 90%. The wholesale acquisition cost (WAC) for Harvoni is $1,125 per pill. It is taken for 8, 12 or 24 weeks based on clinical trial data submitted to the FDA.

    Patient Assistance Program: Support Path – 1-855-769-7284 – www.mysupportpath.com

    Common Drug Interactions: The herb St. John’s wort should be avoided. Antacids and other products to relieve heartburn (stomach problems) can affect how well Harvoni works. Talk to your medical provider about any medications, supplements, herbs or ...

  • Viekira Pak and Viekira XR

    Drug: Viekira Pak (vee-KEE-rah-pak) and Viekira XR

    Summary

    Vikera-image2

    Viekira Pak and Viekira XR is a combination of four drugs approved by the Food and Drug Administration (FDA) to treat chronic hepatitis C (Hep C or HCV) genotype 1. Viekira XR is a extended release formulation of Viekira Pak.  Viekira should be taken with a meal.  The drugs include:

    • Ombitasvir(NS5A inhibitor)-taken twice a day
    • Paritaprevir (protease inhibitor)/ritonavir (protease inhibitor)-taken once-a-day
    • Dasabuvir taken twice daily (morning and evening)

     

    Viekira is taken with and without ribavirin.

    Viekira XR

     

    The overall cure rates of Viekira are 95% to 100%. The wholesale acquisition cost (WAC) for a 12-week treatment course of Viekira is $83,319. It is taken for 12 weeks based on the clinical trial data submitted to the FDA. 

    Patient Assistance Program:    www.viekira.com/proceed-support 1-844-484-3547

    Common Drug Interactions: The herb St. John’s wort ...

  • Epclusa

    Drug: Epclusa (ep-KLOO-suh)

    Summary

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    Epclusa is a combination of two drugs—sofosbuvir, a polymerase inhibitor and velpatasvir, a NS5A inhibitor, combined into one pill, taken once-a-day.Epclusa is taken with or without food. Epclusa is approved by the Food and Drug Administration to treat adults infected with chronic hepatitis C (HCV) genotype 1, 2, 3, 4, 5 and 6.It can be taken with and without ribavirin. Epclusa is manufactured by Gilead Sciences Inc.

    The overall cure rates of Epclusa are up to and over 90%.The wholesale acquisition cost (WAC) for Epclusa is $74,760.00 for a 12-week course of treatment.

    Patient Support: Support Path – 1-855-769-7284 – www.mysupportpath.com

    Common Drug Interactions: The herb St. John’s wort should be avoided.Talk to your medical provider about any medications, supplements, herbs or over-the-counter medications you are taking to prevent any possible problems that may interfere with how well Epclusa will work.

    See the Zepatier

    Drug:  Zepatier (ZEP-ah-teer)

    Summary

    Zepatier
    Zepatier is a combination of two drugs—elbasvir (NS5A inhibitor) and grazoprevir (protease inhibitor) combined into one pill, taken once-a-day.  Zepatier is taken with or without food.   Zepatier is approved by the Food and Drug Administration to treat adults infected with chronic hepatitis C (HCV) genotype 1 and 4.  It can be taken with and without ribavirin.   Zepatier is manufactured by Merck & Co. Inc.

    The overall cure rates of Zepatier are up to and over 90%.  The wholesale acquisition cost (WAC) for Zepatier is $54,600 for a 12-week course of treatment. It is taken for 12 or 16 weeks.

    Patient Support:   Merck Helps www.merckhelps.com/zepatier

    Common Drug Interactions: The herb St. John’s wort should be avoided.  Talk to your medical provider about any medications, supplements, herbs or over-the-counter medications you are taking to prevent any possible problems that may interfere how well Zepatier will work.

    See the Highlights ...

  • Daklinza

    Drug:  Daklinza (dak lin za)

    Summary

    daklinza

    Daklinza is an NS5A inhibitor (daclatasvir) that is approved only in combination with another drug — Sovaldi a polymerase inhibitor (sofosbuvir) — to treat chronic hepatitis C genotype 1 and 3 infections.  It is limited to treated just certain conditions.   It can be taken with and without ribavirin.  Daklinza is manufactured by Bristol-Myers Squibb.  Sovaldi is manufactured by Gilead Sciences Inc.

    The overall cure rates of Daklinza plus sofosbuvir are up to and over 90%.  The wholesale acquisition cost (WAC)  for Daklinza is $64,000 for a 12-week course of therapy;  the WAC cost of a 12-week course of sofosbuvir is $84,000.  The combination is taken for 12 weeks.

    Patient Assistance Programs:

    Daklinzawww.daklinza.bmscustomerconnect.com/patient-support   844-44-CONNECT (844-442-6663)

    Sofosbuvirwww.mysupportpath.com 855-7-MYPATH (1-855-769-7284)

    Common Drug Interactions: The herb St. John’s wort should be avoided.  Antacids and other products to relieve heartburn (stomach problems) can affect how well Sovaldi.  Talk to your medical ...

  • Olysio

    Drug: Olysio (oh li see oh)

    Summary

    olysio
    Olysio (simeprevir) is a protease inhibitor that is taken in combination with and without ribavirin. It is also combined with Sovaldi (sofosbuvir) a polymerase inhibitor manufactured by Gilead Sciences Inc. The combination is approved by the Food and Drug Administration to treat adults infected with hepatitis C genotype 1 patients:

    • Treatment-naïve or treatment-experienced patients without cirrhosis. Treatment duration is 12 weeks.
    • Treatment-naïve or treatment-experienced patients with cirrhosis. Treatment duration is 24 weeks.

     

    Note: Olysio is also approved in combination with pegylated interferon plus ribavirin to HCV genotype 1 and 4 patients. I will only discuss Olysio plus Sovaldi with and without ribavirin to treat genotype 1.

    The wholesale acquisition cost (WAC) for Olysio is $66,360.00. The wholesale acquisition cost for Sovaldi is $84,000 for a 12-week course of therapy.  It is taken for 12 or 24 weeks based on clinical trial data approved by the FDA.

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