• Harvoni

    Drug: Harvoni (har-VOE-nee)

    Summary

    harvoni image

    Harvoni is a combination of two drugs – ledipasvir (NS5A inhibitor) and sofosbuvir (polymerase inhibitor) combined into one pill, taken once-a-day. Harvoni is taken with or without food. Harvoni is approved by the Food and Drug Administration to treat adults infected with hepatitis C (HCV) genotype 1, 4, 5 and 6. It can be taken with and without ribavirin. Harvoni is manufactured by Gilead Sciences Inc.

    The overall cure rates of Harvoni are up to and over 90%. The wholesale acquisition cost (WAC) for Harvoni is $1,125 per pill. It ...

  • Viekira Pak and Viekira XR

    Drug: Viekira Pak (vee-KEE-rah-pak) and Viekira XR

    Summary

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    Viekira Pak and Viekira XR is a combination of four drugs approved by the Food and Drug Administration (FDA) to treat chronic hepatitis C (Hep C or HCV) genotype 1. Viekira XR is a extended release formulation of Viekira Pak.  Viekira should be taken with a meal.  The drugs include:

    • Ombitasvir(NS5A inhibitor)-taken twice a day
    • Paritaprevir (protease inhibitor)/ritonavir (protease inhibitor)-taken once-a-day
    • Dasabuvir taken twice daily (morning and evening)

     

    Viekira is taken with and without ribavirin.

    Viekira XR

  • Epclusa

    Drug: Epclusa (ep-KLOO-suh)

    Summary

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    Epclusa is a combination of two drugs—sofosbuvir, a polymerase inhibitor and velpatasvir, a NS5A inhibitor, combined into one pill, taken once-a-day.Epclusa is taken with or without food. Epclusa is approved by the Food and Drug Administration to treat adults infected with chronic hepatitis C (HCV) genotype 1, 2, 3, 4, 5 and 6.It can be taken with and without ribavirin. Epclusa is manufactured by Gilead Sciences Inc.

    The overall cure rates of Epclusa are up to and over 90%.The wholesale acquisition cost (WAC) for Epclusa is $74,760.00 for a ...

  • Zepatier

    Drug:  Zepatier (ZEP-ah-teer)

    Summary

    Zepatier
    Zepatier is a combination of two drugs—elbasvir (NS5A inhibitor) and grazoprevir (protease inhibitor) combined into one pill, taken once-a-day.  Zepatier is taken with or without food.   Zepatier is approved by the Food and Drug Administration to treat adults infected with chronic hepatitis C (HCV) genotype 1 and 4.  It can be taken with and without ribavirin.   Zepatier is manufactured by Merck & Co. Inc.

    The overall cure rates of Zepatier are up to and over 90%.  The wholesale acquisition cost (WAC) for Zepatier is $54,600 for a ...

  • Daklinza

    Drug:  Daklinza (dak lin za)

    Summary

    daklinza

    Daklinza is an NS5A inhibitor (daclatasvir) that is approved only in combination with another drug — Sovaldi a polymerase inhibitor (sofosbuvir) — to treat chronic hepatitis C genotype 1 and 3 infections.  It is limited to treated just certain conditions.   It can be taken with and without ribavirin.  Daklinza is manufactured by Bristol-Myers Squibb.  Sovaldi is manufactured by Gilead Sciences Inc.

    The overall cure rates of Daklinza plus sofosbuvir are up to and over 90%.  The wholesale acquisition cost (WAC)  for Daklinza is $64,000 for a 12-week ...

  • Olysio

    Drug: Olysio (oh li see oh)

    Summary

    olysio
    Olysio (simeprevir) is a protease inhibitor that is taken in combination with and without ribavirin. It is also combined with Sovaldi (sofosbuvir) a polymerase inhibitor manufactured by Gilead Sciences Inc. The combination is approved by the Food and Drug Administration to treat adults infected with hepatitis C genotype 1 patients:

    • Treatment-naïve or treatment-experienced patients without cirrhosis. Treatment duration is 12 weeks.
    • Treatment-naïve or treatment-experienced patients with cirrhosis. Treatment duration is 24 weeks.

     

    Note: Olysio is also approved in combination with pegylated interferon plus ribavirin to HCV genotype ...