• Vosevi

    Drug: Vosevi (voh-SEV-ee)

    Summary

     

    Vosevi is a combination of three drugs—sofosbuvir (polymerase inhibitor), velpatasvir (NS5A inhibitor), and voxilaprevir (protease inhibitor) combined into one pill taken, once-a-day for 12 weeks.  It is approved by the Food and Drug Administration (FDA) to treat adults with chronic hepatitis C with and without compensated cirrhosis.  Vosevi is manufactured by Gilead Sciences Inc.

    It is approved to treat patients with the following characteristics:

    • HCV genotype(s) 1, 2, 3, 4, 5 or 6 who have been previously treated with a HCV therapy containing an NS5A inhibitor,
    • HCV genotype(s) 1a, or 3 infection and have been treated with an HCV therapy containing sofosbuvir without an NS5A inhibitor
      • Additional benefit of treatment with Vosevi over sofosbuvir/velpatasvir was not shown in adults with genotype 1b, 2, 4, 5 or 6 infection previously treated with sofosbuvir without a NS5A inhibitor.

     

    The overall cure rates of Vosevi are 91% to 100% in patients who had ...

  • Sovaldi

    Drug: Sovaldi (soh-VAHL-dee)

    Summary

    sovaldi
    Sovaldi is a polymerase inhibitor that is taken in combination with ribavirin. It is taken once-a-day with or with or without food. Sovaldi is approved by the Food and Drug Administration (FDA) to treat adults infected with hepatitis C (HCV) genotype 2 and 3. Sovaldi is manufactured by Gilead Sciences Inc. Note: Sovaldi is also approved in combination pegylated interferon to treat genotype 1 and 4. This review will only discuss Sovaldi plus ribavirin to treat genotype 2 and 3.

    Initial FDA Approval: 2013
    The wholesale acquisition cost (WAC) for Sovaldi is $84,000 for a 12-week course of therapy. It is taken for 12 or 24 weeks based on clinical trial data based on clinical trial data approved by the FDA.

    Patient Support: Support Path – 1-855-769-7284 – www.mysupportpath.com

    Common Drug Interactions:  The herb St. John’s wort should be avoided.  Antacids and other products ...

  • Epclusa

    Drug: Epclusa (ep-KLOO-suh)

    Summary

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    Epclusa is a combination of two drugs—sofosbuvir, a polymerase inhibitor and velpatasvir, a NS5A inhibitor, combined into one pill, taken once-a-day.Epclusa is taken with or without food. Epclusa is approved by the Food and Drug Administration to treat adults infected with chronic hepatitis C (HCV) genotype 1, 2, 3, 4, 5 and 6.It can be taken with and without ribavirin. Epclusa is manufactured by Gilead Sciences Inc.

    The overall cure rates of Epclusa are up to and over 90%.The wholesale acquisition cost (WAC) for Epclusa is $74,760.00 for a 12-week course of treatment.

    Patient Support: Support Path – 1-855-769-7284 – www.mysupportpath.com

    Common Drug Interactions: The herb St. John’s wort should be avoided.Talk to your medical provider about any medications, supplements, herbs or over-the-counter medications you are taking to prevent any possible problems that may interfere with how well Epclusa will work.

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